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422 21st Street
Denver, CO 80205
FOR SALE · Active
$1,000,000
$390 / Sqft
4
Beds
2
Baths
2,565
Sqft
0.14
Acres
1886
Yr. Built
MLS# 6487194
Cumulative Days on Market: 257 · Includes prior listings · Currently listed since 02/10/26 · Data provided by the MLS.

Property Description

Rare and storied mixed-use opportunity situated on a highly visible 6, 270-square-foot corner lot in the heart of Five Points. The property features a historic five-bedroom residence and a separate office building, totaling approximately 6, 565 square feet of improvements on a single parcel. Ideally positioned just steps from Benedict Fountain Park, the RTD 27th and Welton Light Rail Station, neighborhood coffee shops and restaurants, and only minutes from Downtown Denver and Uptown, the property offers an exceptional blend of urban convenience, historic character, and neighborhood connectivity. The property includes an approximately 2, 565-square-foot historic residence with five bedrooms and two bathrooms, currently operating as a successful Airbnb and providing immediate income or the opportunity for owner occupancy. Tucked behind the residence is a rare, private rear
patio, offering an inviting outdoor retreat ideal for entertaining, relaxing, or complementing a live / work lifestyle—an uncommon amenity for a property so close to downtown. Complementing the residence is a separate office duplex totaling approximately 4, 000 square feet, comprised of two approximately 2, 000-square-foot office suites, one of which is currently leased on a month-to-month basis, providing immediate cash flow while preserving flexibility for future occupancy, repositioning, or redevelopment.
Located within the Clements Historic District, this unique property offers exceptional visibility, walkability, and access to some of Denver’s most desirable dining, entertainment, cultural, and transit amenities. Whether envisioned as an investment, corporate headquarters with supplemental income, creative office campus, live / work environment, boutique hospitality concept, or long-term repositioning opportunity, this one-of-a-kind asset presents remarkable versatility in one of Denver’s most vibrant and historically significant neighborhoods.

Property Highlights

Property Type
Residential
Property Sub Type
Single Family Residence
Bedrooms
4
Total Bathrooms
2
Living Area
2,565
Price / Sqft
$390
Acres
0.14
Year Built
1886
Cumulative Days on Market
257

Location

City/Township
Denver
Subdivision
Five Points
County
Denver
Zoning
C-MX-5

Property Details

Price
$1,000,000
Property Type
Residential
Property Sub Type
Single Family Residence

Building

Structure Type
House
Levels
Two
Total Area
2,565

Community

Local Schools

Elementary School
Whittier E-8
Middle School
Cole Arts And Science Academy
High School
East
School District
Denver 1

Interior Features

Bedrooms and Bathrooms

Total Bathrooms
2
Bathrooms on Main Level
1
Full Bathrooms
1
3/4 Bathrooms
1
Bedrooms
4
Bedrooms on Main Level
1

Area and Spaces

Living Area
2,565
Above Grade Finished Area
2,565

Heating and Cooling

Heating Features
Hot Water

Building Details

Construction

Year Built
1886

Materials

Construction Materials
Brick
Roof
Composition

Terms

Terms

Ownership
Individual
Exclusions
Personal Property.
Special Conditions
None
Special Terms
Cash, Conventional
Cumulative Days on Market
257

Taxes

Tax

Tax (Annual)
$15,636

Heating, Cooling & Utilities

Cooling Features
None

Utilities

Sewer
Public Sewer

Lot

Acres
0.14
Lot Size
6,270
Lot Size Area Sq Ft
6,270
Lot Features
Level
Listed by Kentwood Commercial, Llc, karen@kentwoodcommercial.com, 303-947-3665
Listing Data last updated 10/25/2026 01:00 am
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Property History

Yesterday
Property information last updated
62 days ago
Date of last price change
256 days ago
Status Active. This is the date the listing was placed on market.
Cumulative Days on Market: 257 days (includes prior listings) · Currently listed since February 10, 2026. Data provided by the MLS.

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